Key publications


Clinical Study Phase 1 - Marsyas I

Study Report - Synopsis
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Papers

Cell secretome based drug substances in regenerative medicine: when regulatory affairs meet basic science
Annals of Translational Medicine. Feb. 2017

Beer L, Mildner M, Ankersmit HJ
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Peripheral blood mononuclear cell secretome for tissue repair
Apoptosis. 2016 Oct 1. [Epub ahead of print]

Beer L, Mildner M, Gyöngyösi M, Ankersmit HJ
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Dying blood mononuclear cell secretome exerts antimicrobial activity
Eur J Clin Invest. 2016 Oct;46(10):853-63. doi: 10.1111/eci.12667. Epub 2016 Sep 26.

Kasiri MM, Beer L, Nemec L, Gruber F, Pietkiewicz S, Haider T, Simader EM, Traxler D, Schweiger T, Janik S, Taghavi S, Gabriel C, Mildner M, Ankersmit HJ
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Paracrine Factors from Irradiated Peripheral Blood Mononuclear Cells Improve Skin Regeneration and Angiogenesis in a Porcine Burn Model
Sci Rep. 2016 Apr 29;6:25168. doi: 10.1038/srep25168.

Hacker S, Mittermayr R, Nickl S, Haider T, Lebherz-Eichinger D, Beer L, Mitterbauer A, Leiss H, Zimmermann M, Schweiger T, Keibl C, Hofbauer H, Gabriel C, Pavone-Gyöngyösi M, Redl H, Tschachler E, Mildner M, Ankersmit HJ
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Analysis of the secretome of apoptotic peripheral blood mononuclear cells: impact of released proteins and exosomes for tissue regeneration
Sci Rep. 2015 Nov 16;5:16662. doi: 10.1038/srep16662.

Beer L, Zimmermann M, Mitterbauer A, Ellinger A, Gruber F, Narzt M-S, Zellner M, Gyöngyösi M, Madlener S, Simader E; Gabriel C, Mildner M, Ankersmit HJ
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The secretome of apoptotic human peripheral blood mononuclear cells attenuates secondary damage following spinal cord injury in rats
Exp Neurol. 2015 Mar 19. pii: S0014-4886(15)00081-3. doi: 10.1016/j.expneurol.2015.03.013. [Epub ahead of print]

Haider T, Höftberger R, Rüger B, Mildner M, Blumer R, Mitterbauer A, Buchacher T, Sherif C, Redl H, Gabriel C, Gyöngyösi M, Fischer MB, Lubec G, Ankersmit HJ
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High dose ionizing radiation regulates micro RNA and gene expression changes in human peripheral blood mononuclear cells
BMC Genomics. 2014 Sep 25;15:814; doi: 10.1186/1471-2164-15-814

Beer L, Seemann R, Ristl R, Ellinger A, Kasiri MM, Mitterbauer A, Zimmermann M, Gabriel C, Gyöngyösi M, Klepetko W, Mildner M1, Ankersmit HJ
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Secretomes of Apoptotic Mononuclear Cells Ameliorate Neurological Damage in Rats with Focal Ischemia
F1000 Research 2014, 3:131

Altmann P, Mildner M, Haider T, Traxler D, Beer L, Ristl R, Golabi B, Gabriel C, Leutmetzer F, Ankersmit HJ
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Long-acting beneficial effect of percutaneously intramyocardially delivered secretome of apoptotic peripheral blood cells on porcine ischemic left ventricular dysfunction
Biomaterials. 2014 Jan 15. pii: S0142-9612(13)01567-6. doi: 10.1016/j.biomaterials.2013.12.071. [Epub ahead of print]
Pavo N, Zimmermann N, Mildner M, Petrási Z, Petneházy O, Fuzik J, Jakab A, Gabriel C, Sipos W, Maurer G, Gyöngyösi M, Ankersmit HJ
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Secretome of Peripheral Blood Mononuclear Cells Enhances Wound Healing
PLOS ONE, 22 March 2013, 10.1371/journal.pone.0060103

Mildner M, Hacker S, Haider T, Gschwandtner M, Werba G, Barresi C, Zimmermann M, Golabi B, Tschachler E, Ankersmit HJ
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Mononuclear cell secretome protects from experimental autoimmune myocarditis
European Heart Journal. 2013 Jan; doi:10.1093/eurheartj/ehs459 (Advance Access)
Hoetzenecker K, Zimmermann M, Hoetzenecker W, Schweiger T, Kollmann D, Mildner M, Hegedus B, Mitterbauer A, Hacker S, Birner P, Gabriel C, Gyöngyösi M, Blyszczuk P, Eriksson U, Ankersmit HJ
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Irradiated cultured apoptotic peripheral blood mononuclear cells regenerate infarcted myocardium
Eur J Clin Invest. 2009 Jun;39(6):445-56. Epub 2009 Apr 16

Ankersmit HJ, Hoetzenecker K, Dietl W, Soleiman A, Horvat R, Wolfsberger M, Gerner C, Hacker S, Mildner M, Moser B, Lichtenauer M, Podesser BK
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Intravenous and intramyocardial injection of apoptotic white blood cell suspensions prevents ventricular remodelling by increasing elastin expression in cardiac scar tissue after myocardial infarction
Basic Research Cardiology 2011 Jun;106(4):645-55

Lichtenauer M, Mildner M, Baumgartner A, Hasun M, Werba G, Beer L, Altmann P, Roth G, Gyöngyösi M, Podesser BK, and Ankersmit HJ
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Secretome of apoptotic peripheral blood cells (APOSEC) confers cytoprotection to cardiomyocytes and inhibits tissue remodelling after acute myocardial infarction: a preclinical study
Basic Res Cardiol. 2011 Nov;106(6):1283-97

Lichtenauer M, Mildner M, Hoetzenecker K, Zimmermann M, Podesser BK, Sipos W, Berényi E, Dworschak M, Tschachler E, Gyöngyösi M, Ankersmit HJ
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Secretome of apoptotic peripheral blood cells (APOSEC) attenuates microvascular obstruction in a porcine closed chest reperfused acute myocardial infarction model: role of platelet aggregation and vasodilation
Basic Res Cardiol. 2012 Sep;107(5):292. Epub 2012 Aug 17

Hoetzenecker K, Assinger A, Lichtenauer M, Mildner M, Schweiger T, Starlinger P, Jakab A, Berényi E, Pavo N, Zimmermann M, Gabriel C, Plass C, Gyöngyösi M, Volf I, Ankersmit HJ
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Apoptotische Leukozyten und deren Sekretionsprodukt. Relevanz für die Herzinfarkttherapie beim Menschen
Wiener klinisches Magazin 5/2011

Lichtenauer M, Mildner M, Gyöngyösi M, Ankersmit HJ
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PhD-Theses

Cardiac regeneration in ischaemic cardiomyopathy
Cell-free cardiac regeneration in ischaemic cardiomyopathy: The paracrine regenerative effect of the secretome of apoptotic peripheral blood mononuclear cells (APOSEC)
Noemi Pavo (2016)

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Therapeutic Capacity of Apoptotic Mononuclear Cell Secretome in Experimental Spinal Cord Injury
Thomas Haider (2016)

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The effects of high dose ionizing radiation on transcriptional regulation and paracrine signaling inhuman peripheral blood mononuclear cells
Lucian Beer (2015)

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The secretome of mononuclear cells as a therapeutic tool in myocardial infarction and myocarditis: an experimental study
Konrad Hoetzenecker (2012)

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Secretome of apoptotic cells causes cardioprotection and inhibits ventricular remodeling after acute myocardial infarction
Michael Lichtenauer (2011)

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Latest News
Mar
31

MarsyasI - clinical phase 1 study completed

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Nov
24

Paper on content analysis of APOSEC recently published

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